In vitro activity of TP-271 against Mycobacterium abscessus, Mycobacterium fortuitum, and Nocardia species.

نویسندگان

  • Michael Cynamon
  • Jeff Jureller
  • Balaji Desai
  • Krithika Ramachandran
  • Mary Sklaney
  • Trudy H Grossman
چکیده

The in vitro activities of TP-271, a novel fluorocycline antimicrobial, against 22 isolates of Mycobacterium abscessus, 22 isolates of Mycobacterium fortuitum, and 19 isolates of Nocardia spp. were studied by a microtiter broth dilution method. The MIC(90)s for M. abscessus, M. fortuitum, and Nocardia spp. were 0.5 μg/ml, 0.03 μg/ml, and 8 μg/ml, respectively. TP-271 was significantly more active than the respective control drug in virtually all tests.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 56 7  شماره 

صفحات  -

تاریخ انتشار 2012